VWF and osteomyelitis: During the progression of osteomyelitis, S. aureus forms unique staphylococcal abscess communities (SACs).54 Specifically, S. aureus attacks immune cells, such as neutrophils, and collaboratively creates a fibrin pseudo-capsule using coagulase and von Willebrand Factor (VWF).55 This fibrin pseudo-capsule acts as a protective barrier and attracts immune cells, many of which undergo necrosis.