The previous study has shown that PTENα/β promotes tumor progression in liver cancer cells by interacting with WDR5 to recruit the SET1/MLL complexes to the promoters of the PTENα/β-target genes, such as NOTCH3, SLC12A5 and TCF19, the broadly studied oncogenes [15, 42–45]. The gene discussed is WDR5; the disease is liver cancer.