We therefore asked whether expression of selected SLE associated genes C1QB, C1QA, C1R, C1S, C3, DNASE1L3, ACP2, AGER, CTBB, DNASE1, FAS and TMEM17336–40 generally spatially overlapped across the tissue irrespective of zonation (Fig. 3i and Supplementary Fig. 3h, i). This evidence concerns the gene DNASE1 and systemic lupus erythematosus.