EIF4EBP1 and central nervous system cancer: We next evaluated pro-tumorigenic functions of 4EBP1 in glioma cells in vivo by first injecting control (shScr) and 4EBP1 kd U-87 MG cells into the flanks of NOD SCID mice and observed that 4EBP1 depleted cells formed significantly smaller tumors as compared to controls (Fig. 6F).