In line with this, overexpression of 4EBP1AA in HeLa cells promoted tumor growth relative to control (EV) HeLa cells when injected into the flanks of immunocompromised mice, which was not the case with overexpression of the eIF4E-non-binding mutant 4EBP1AA, YL (Fig. 5G, H). The gene discussed is EIF4E; the disease is neoplasm.