PIAS2 and thyroid gland undifferentiated (anaplastic) carcinoma: These results revealed PIAS2 as a dosage-dependent protein in anaplastic thyroid cancer cells, since both its downregulation (PIAS2b-dsRNAi) and its overexpression (FLAG-hPIAS2a, FLAG-hPIAS2b, or EGFP-C1-hPIAS2b) were deleterious.