In CAM453, a duplication event (chr8:126694685-130657526) was identified in both the tumor and organoid (CN 0.4 and 108.5 respectively) using GRIDSS-LINX29, suggesting that the amplicon was present at a low CN in the tumor and clones harboring the MYC ecDNA expanded in the derived organoid (Fig. 4C). Here, MYC is linked to neoplasm.