To complicate matters, there are also reports of METTL8 binding to mRNAs including ARID1A and MAPKBP1: the former leading to increased ARID1A protein levels that promote migration of breast cancer cells; while the latter results in the inhibition of MAPKBP1 translation thereby inhibiting the JNK pathway, which enhances mouse embryonic stem cell differentiation [20, 21]. This evidence concerns the gene METTL8 and breast carcinoma.