For instance, PDGFRA amplification occurs in ~13% GBM and PDGFB overexpression alone is sufficient to drive gliomagenesis [24, 46]); 9% of GBM tumors overexpress ERBB3 via miR-205 inactivation [47]; and EPHA7 overexpression portends poor patient prognosis in both primary and recurrent GBM [48]. This evidence concerns the gene PDGFB and glioblastoma.