METTL8 and glioblastoma: Since METTL8 indirectly controls mitochondrial translation and respiration in GSC, mitochondrial translation and OXPHOS inhibitors would conceptually mimic METTL8 loss, but these compounds are unlikely suitable for GBM treatment due to the lack of knowledge as to whether they can pass through the blood-brain-barrier, their poor plasma stability, and toxicities [51–54].