Correlative analysis of METTL8 mRNA with cancer-related proteins in the TCGA RPPA (Reverse Phase Protein Array) glioma dataset unveiled significant positive correlations between METTL8 levels and that of phospho- and total EGFR/ Akt, cementing the intimate link between METTL8 and the RTK/Akt pathway (Supplementary Fig. 4C). This evidence concerns the gene AKT1 and central nervous system cancer.