The serum DKK1 concentration in OI children was negatively correlated with height (r = − 0.282), height Z score (r = − 0.292), ALP concentration (r = − 0.304), lumbar BMD (r = − 0.276), BMD Z score of the lumbar spine and femoral neck (r = − 0.32; r = − 0.27) (all P < 0.05). This evidence concerns the gene DKK1 and osteogenesis imperfecta.