TNF and Cachexia: Similarly in the current study, CRP, TNFα, IL-6, and IL-8 were all significantly related to QL-G, QL-FS, and QL-SS, supporting this relationship and the utility of cachexia biomarkers in predicting QoL and conversely the potential of QoL assessments in predicting the expression of pro-inflammatory cytokines, systemic inflammation, and extent of disease.