Knockout of IL-1α, tumor necrosis factor-alpha (TNF-α), and C1q released from senescent microglia prolonged the survival time of SOD1G93A ALS mouse model (Guttenplan et al. 2020), indicating that targeting SASP improves disease phenotype in ALS mouse model (Granucci et al. 2019). This evidence concerns the gene TNF and amyotrophic lateral sclerosis.