RFC1 and neuropathy: Peripheral neuropathy is one hallmark feature of cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS): a multisystem, adult-onset, slowly-progressive disorder with autosomal recessive inheritance.72, 74 In 2019, biallelic pentanucleotide AAGGG expansions in the second intron of RFC1 were identified as causing CANVAS.72