Thymoquinone suppresses NF-κB activation induced by various carcinogens and inflammatory agents, and NF-κB inhibition is due to the inhibition of IkB kinase (IKK) activation, leading to suppression of NF kappa B inhibitor alpha (IκBα) phosphorylation and degradation.17The intense antibacterial activity ofNigella sativacan be used as a therapeutic agent or adjuvant in bacterial infections. Here, NFKBIA is linked to bacterial infectious disease.