TNF and infection: The lactoferrin enzyme in the enzyme paste also acts as an antibacterial and tends to be bacteriostatic by binding to Fe3+ ions, which are needed for the growth of microorganisms.22Enzyme toothpaste can prevent infection so that it can indirectly reduce inflammatory activity, as illustrated by the results of this study, where there was no significant difference between the expression of PGE-2, MMP-9, and TNF-α in the treatment group and the enzyme group.