IFNA1 and systemic lupus erythematosus: The finding that hallmark autoantibodies linked to SLE pathogenesis were only associated with disease subsets with high IFN-I activity, as well as the unique association of IFN-I with transcriptional fingerprints linked to disease activity (plasmablasts and granulopoiesis), further supports the notion that IFN-I is the main IFN type that dictates the disease outcome in a subset of patients with SLE.