While new technologies have been used to overcome this limitation and measure the majority of IFN-αs in SLE using a single assay (e.g., single-molecule array [Simoa] digital ELISA technology),27,28 other IFN-I members that may have functional relevance in SLE were excluded (e.g., IFN-β, IFN-ε, IFN-κ, and IFN-ω). This evidence concerns the gene IFNB1 and systemic lupus erythematosus.