CD274 and neoplasm: The rates of PD-L1 positivity within the TMA were lower than expected; this may be a consequence of sampling during the creation of the TMA, with samples more likely to be taken from the centre of the tumour specimen or the result of age-related deglycosylation of the extracellular domain of PD-L1,50 and indicates that caution needs to be taken in the interpretation of these particular results.