In contrast, both double Ifnar1-/-Ifngr1-/- and Stat1-/- mice displayed evident skin lesions marked by necrosis of the overlying epidermis and hardening features, surrounded by an indurated red halo (Fig 1H, red arrows), which resembled skin eschars in scrub typhus patients [37–39]. The gene discussed is IFNAR1; the disease is scrub typhus.