In contrast, both double Ifnar1-/-Ifngr1-/- and Stat1-/- mice displayed evident skin lesions marked by necrosis of the overlying epidermis and hardening features, surrounded by an indurated red halo (Fig 1H, red arrows), which resembled skin eschars in scrub typhus patients [37–39]. Here, IFNGR1 is linked to scrub typhus.