Despite these important limitations, the results reinforce the role of LRV1 in the host immune response in the early stages of infection, with differential expression of several genes related to Type I and Type II Interferon signaling pathways, non-genomic actions of 1.25 dihydroxy vitamin D3, OAS /RNAse L, and RIG-like receptors. The gene discussed is RNASEL; the disease is infection.