In the outbred rat model of CMT1A,22 rats can have varying levels of rodent Pmp22 expression, giving rise to a spectrum of phenotype severities, including variations in the expression of lipid metabolism-related genes.22,49 To understand how these transcriptional changes influence the CMT1A lipid profiles, we performed lipidomics on the sciatic nerves of 5-week-old C3 mice. The gene discussed is PMP22; the disease is Charcot-Marie-Tooth disease type 1A.