Attie and colleagues inhibited APOC3 using an antisense oligonucleotide (ASO) in LDLR WT BTBR OB mice, which did not prevent DKD progression (22), consistent with the idea that TRL-associated APOC3 may play a role in DKD rather than HDL-associated APOC3. The gene discussed is LDLR; the disease is diabetic kidney disease.