CD4T1 and CD4T10 included genes for costimulatory molecules OX40 (TNFRSF4) and GITR (TNFRSF18), both of which have been described to promote survival and proliferation of CD4+ Teff and have been targets of autoimmune disease therapeutics (Supplemental Table 4) (35–39). Here, CD4 is linked to autoimmune disease.