Based on existing data on the pathogenesis of axSpA, we decided to expand the search for predictors of response to biological treatment to include variables that were not previously considered as potential predictors: the variable associated with inflammation (Hp), related to increased intestinal permeability (zonulin, IBD) and disturbed intestinal flora (repeated courses of antibiotics due to frequent infections) [10–13]. The gene discussed is HP; the disease is infection.