On the opposite side, a former study showed that Gal-1 upregulated profile weakened the apoptosis and autophagy in addition to production of inflammatory cytokines induced by LPS (lipopolysaccharide) in hPDLSC (human periodontal ligament stem cells) suggesting that Gal-1 could possess potential therapeutic effects on the inflammatory process of periodontal disease [56]. The gene discussed is LGALS1; the disease is periodontal disorder.