Moreover, they suggested that higher GCF Gal-1 values in periodontal disease groups could be attributed to extracellular matrix and collagen fibrils destruction regarding gingivitis whereas for periodontitis periodontal ligament as well as alveolar bone destruction could be the cause and that Gal-1 elevated expression was an effort to help limiting this destruction taking place in periodontal disease. This evidence concerns the gene LGALS1 and gingivitis.