ROC curve analysis showed both markers to have excellent diagnostic ability in discriminating periodontitis and gingivitis from healthy individuals (100% diagnostic accuracy for Gal-1 and 93% for Gal-3, AUC > 0.9) and acceptable diagnostic ability in discriminating periodontitis from gingivitis patients (73% diagnostic accuracy for Gal-1 and 80% for Gal-3, AUC > 0.7). Here, LGALS3 is linked to periodontitis.