Endothelial cell-selective deletion of the miR-15a/16–1 cluster could upregulate the protein expression of pro-angiogenic factors VEGFA and FGF2 (fibroblast growth factor 2), and their receptors VEGFR2 and FGFR1 (fibroblast growth factor receptor 1) after ischemic stroke were negative regulators for long-term neurological recovery [37]. The gene discussed is VEGFA; the disease is ischemic stroke.