While a recent haplotype analysis of 38 unrelated carriers of TP53 p.Arg337His found two homozygous patients with early onset of cancer (ages 6 and 9 years old) with a compound TP53 p.Arg337His and XAF1 p.E134* haplotype, other reports did not rule out additional co-variants[43]. The gene discussed is TP53; the disease is cancer.