While this SNP has limited impact on cancer risk, data from cell lines and mice models show that this SNP markedly affects the response of P53 to nutrient alterations, driving increased inflammation in mice on a high-fat diet and alters the ability of mutant P53 to bind and inhibit the PGC-1α metabolism regulator thus inducing cancer-promoting metabolism [53]. The gene discussed is PPARGC1A; the disease is cancer.