Notably, TP53 p.Arg181Cys has been described in one other pediatric case—a 1 year old boy with rhabdomyosarcoma, who was later diagnosed with adrenocortical carcinoma and osteosarcoma at 2 years of age, as a result of whole body MRI surveillance, demonstrating the importance of genetic screening for TP53 p.Arg181Cys and subsequent surveillance in high-risk population [6]. This evidence concerns the gene TP53 and osteosarcoma.