In a second cohort published by Hamaeh et al. which examined 453 patients with early onset or familial breast cancer of Arab descent from the Jerusalem area, The West bank and Gaza, the same TP53, p.Arg181Cys variant was found in 9 breast cancer probands (1.9%) in the Jerusalem area and lead to cascade detection of the variant in an additional 5 breast cancer patients and 5 healthy carriers [20]. This evidence concerns the gene TP53 and breast cancer.