The types of cancers diagnosed were characteristic of LFS and included breast cancer—16 patients, (53.3%, of them, 6 patients were HER2-positive 2 patients were HER2-low and 3 patients were diagnosed before the age of 31); primary high-grade CNS tumors—6 patients (20%); and sarcomas—3 patients (10.0%). Here, ERBB2 is linked to central nervous system neoplasm.