The upregulation of mmu-miR-511-5p following infection with RH strain may be attributed to that: T. gondii virulent strain was found to produce rhoptry protein kinase (ROP16) [44], that can activate signal transducer and activator of transcription 6 (STAT6), leading to the induction of arginase, an enzyme that associates alternatively activated macrophages M2, leading to increased miR-511 expression inside the macrophages, and subsequently an upregulation of its serum level [42, 49, 53, 54]. The gene discussed is STAT6; the disease is infection.