CD8A and neoplasm: A study examining DC-OVA-derived exosomes (EXODC) showed that EXODC can more effectively stimulate naive OVA-specific CD8 + T cell proliferation and differentiation into cytotoxic T lymphocytes in vivo as compared to EG7 tumor cell line-derived exosomes (TEXEG7); the stronger killing activities by EXODC against lung tumor cells were attributed to the expression of co-stimulatory molecules such as CD40 and CD80 [146].