Data from 371,695 participants in the UK Biobank and two large genome-wide association studies [22] showed that genetically lower FXI levels were associated with lower risk of ischemic stroke [odds ratio (OR) 0.47, 95% confidence interval (CI) 0.36–0.61; p < 0.001] and venous thromboembolism (OR 0.1, 0.07–0.14; p < 0.001), but not with major bleeding (OR = 0.7, 0.45–1.04) [22]. This evidence concerns the gene F11 and ischemic stroke.