In neonates suffering from hypoxic-ischemic encephalopathy (HIE), levels of B2M in cerebrospinal fluid are significantly increased and correlates with the severity of HIE, which suggests a promising avenue for utilizing B2M as a marker to monitor the extent of inflammation and response to treatment in HIE cases (Carreras et al. 2023). The gene discussed is B2M; the disease is perinatal asphyxia.