Within the realm of oncology, the overexpression of B2M induced the epithelial-mesenchymal transition (EMT) within neoplastic cells, and enhanced the migratory and invasive potential of various cancer types cells including prostate, breast, lung, and renal carcinomas, consequently promoting their metastasis to soft tissues and bone (Josson et al. 2011). The gene discussed is B2M; the disease is cancer.