BDNF and progressive pseudorheumatoid arthropathy of childhood: The decline of BDNF in the mPFC has been found in both clinical and preclinical studies in mental disorders related to estradiol fluctuations, such as premenstrual dysphoric disorder (Oral et al. 2015), PPD (Lee et al. 2021), and perimenopausal depression (Harder et al. 2022).