Using protein-protein network analysis, the MCODE algorithm, and the highest degree of circRNA nodes, the regulatory axis of hsa_circRNA7329/hsa-miR-9/SCD was identified, which may regulate SCD via hsa-miR-9 to promote macrophage-mediated inflammation and pathological angiogenesis, leading to the development of AMD. This evidence concerns the gene SCD and age-related macular degeneration.