The correlation between STAT3 and visual cycle-related genes such as RGR, RDH5, and RDH11 is still unknown, and we speculate that the deposition of lipofuscin with aging leads to retinal stress, which may be expected to be a new target for the treatment of subtype an AMD by activating the transcriptional regulation of visual cycle-related genes such as RGR, RDH5, and RDH11 by STAT3 transcription factors. Here, RGR is linked to age-related macular degeneration.