The results of Yang’s study also showed that Circ_001422 is overexpressed in OS cell lines and promotes tumor development by modulating the miR-195-5p/FGF2/PI3K/Akt pathway.25 Higher circ_001422 expression accelerates proliferative and invasive potentials of OS through absorbing miRNA-195-5p.25 Our study found the biological function of circ-LOM7 in OS depended on absorbing miR-21-5p. This evidence concerns the gene AKT1 and neoplasm.