At the same time, related studies have found that the HE4‐encoding gene WFDC2 can induce the expression of matrix metalloproteinase 2 (MMP2) by activating the AKT signaling pathway, promote epithelial–mesenchymal transition, and then promote the metastasis of ovarian cancer cells.22 The gene discussed is WFDC2; the disease is ovarian carcinoma.