ALB and liver dysplastic nodule: However, the umbrella review revealed that low-protein diets had no significant improvement on all-cause mortality (RR 0.38, 95% CI 0.10 to 1.44) (low-quality evidence), renal failure (RR 1.16, 95% CI 0.38 to 3.59) (low-quality evidence), GFR (MD -0.73, 95% CI -2.30 to 0.83) (very low-quality evidence), CrCl (MD -2.39, 95% CI -5.87 to 1.08) (very low-quality evidence), or 24-hour urinary albumin excretion (MD 0.00, 95% CI -0.07 to 0.07) (very low-quality evidence) in DN patients (Figure 2) (Table 2).