GNRHR and adenomyosis: The rate of infertility among patients with adenomyosis is approximately 22% (4).Gonadotropin-releasing hormone agonists (GnRH-a) are widely used in adenomyosis therapy, and not only do they exert direct anti-proliferative effects on lesions, but they can also precipitate a hypoestrogenic state via competitive downregulation of pituitary GnRH receptors (GnRHRs) to treat adenomyosis (5).