XDH and diabetic kidney disease: Increased accumulation of LDs in DKD was found (22, 52, 85),and an increase in LDs in glomerular and/or tubular cells of the kidneys of hyperglycemic mice was accompanied by an increase in markers of oxidative stress (xanthine oxidoreductase (XOR) and nitrotyrosine with tail-interacting protein of 47 kDa (TIP47)) (86).