The expression of genes involved in the fatty acid β-oxidation pathway, such as (22),and SREBP, a transcription factor regulating the synthesis of FAs, induced FASN and acetyl CoA carboxylase to increase the cytosolic TG content (98, 99),and it was found that Streptozotocin(STZ)-induced diabetic rat renal cortex and DKD patients’ renal tubules increased their TG content and increased sterol regulatory element-binding proteins 1(SREBP-1) expression in the renal tubular epithelium of STZ-induced diabetic rats (100–103). The gene discussed is SREBF1; the disease is diabetic kidney disease.