Renal biopsies from patients with DKD showed decreased expression of genes encoding PPAR-α and PPARδ and their downstream acyl-coenzyme A oxidase and carnitine palmitoyl transferase (CPT1) involved in the fatty acid β-oxidation pathway, and SREBP, a transcription factor regulating FA synthesis, induced fluorescent antibody serum neutralization (FASN) and acetyl Coenzyme A(CoA) carboxylation. This evidence concerns the gene FASN and diabetic kidney disease.