In terms of sphingolipids metabolism, the rs267734 gene variant of Ceramide synthases 2 (CerS2) in patients with DKD resulted in increased proteinuria (108), and polymorphisms in the Sphingosine-1-phosphate lyase 1(SGPL1) gene encoding S1P lyase 1 were associated with reduced enzymatic activity of S1P lyase 1 and the development of nephropathy. Here, SGPL1 is linked to diabetic kidney disease.