Adipose triglyceride lipase (ATGL) is a critically important signaling node for lipophagy, and sirtuin 1 (SIRT1) acts as a key mediator downstream of ATGL whose role is to promote lipophagy (150) and decreased expression of SIRT1 in the kidney promotes DKD (151–153). This evidence concerns the gene SIRT1 and diabetic kidney disease.