Clinical studies have shown that the polymorphism rs4578621 in the Perilipin(PLIN) gene is associated with type 2 diabetes mellitus, and the expression of Perilipin 2(PLIN2) is upregulated in the kidneys of diabetic db/db mice (103, 112),which may be the reason. This evidence concerns the gene PLIN2 and type 2 diabetes mellitus.