In addition, the impact of OVX in the presence of APOE4 may also involve other sex steroid hormones and related hormones such as follicle-stimulating hormone (FSH)—for example, lowering FSH levels in APOE4/4 may mitigate the AD pathology and behavioral impairments associated with APOE4 (55). This evidence concerns the gene BRD2 and Alzheimer disease.