Plasma LRG1 at admission >60 μg/ml (yes vs. no) [hazard ratio (HR) = 3.213, P = 0.041], plasma LRG1 at D7 > 60 μg/ml (yes vs. no) (HR = 3.299, P = 0.025), history of hyperlipidemia (yes vs. no) (HR = 4.572, P = 0.008), history of diabetes mellitus (yes vs. no) (HR = 2.599, P = 0.050), WBC ≥10 × 109/L (yes vs. no) (HR = 3.425, P = 0.032), LDL-C ≥ 3.4 mmol/L (yes vs. no) (HR = 3.129, P = 0.025), cTnI ≥4.4 ng/ml (yes vs. no) (HR = 3.384, P = 0.033), and Th17 cells ≥4.4% (yes vs. no) (HR = 6.885, P = 0.011) were related to elevated MACE risk. Here, TNNI3 is linked to diabetes mellitus.