Furthermore, gene set enrichment analysis revealed that duct-acinar cells presented enrichment in genes involved in cytokine-mediated signaling (Figure 3E) as compared to the rest of the duct cell subpopulations in T1D (Supplementary Table 7), including CXCL1 and 3 and IL1α (Figure 3F). This evidence concerns the gene IL1A and type 1 diabetes mellitus.