Neurotrophin-3 holds promise as a pharmacological target for mood disorders due to its influence on monoamine neurotransmitters, regulation of synaptic plasticity and neurogenesis, enhancement of brain-derived neurotrophic factor (BDNF) signaling, and modulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is implicated in the neurobiological processes underlying mood and anxiety disorders (52). This evidence concerns the gene BDNF and mood disorder.