The result showed that gene, including CASP8, FADD, CASP6, TAB3, PSTPIP2, TNFAIP3, PARP1, GSDMD, MKLK, IRF1, RIPK1, TRADD, PYCARD, was upregulated in HCC, whereas only NLRP3, AIM2, and MEFV were significantly downregulated in HCC samples (Figure 2D). Here, NLRP3 is linked to hepatocellular carcinoma.