IRAK3 and essential thrombocythemia: Despite evidences from conditional genetically ablated mice demonstrating HIF1α role in promoting myeloid cell-mediated inflammation and pro-inflammatory gene expression (53, 54), a meta-analysis of sepsis leukocyte datasets uncovered a strong correlation between elevated HIF1α and IRAK-M levels in independent cohorts of sepsis patients exhibiting the hallmarks of ET (32).