Furthermore, we observed that co-inhibitory molecules and exhaustion (CD272, LAG-3/CD223, and TIM-3) were not differently expressed on three monocyte subsets under normal physiological conditions (Figures 4A, C), although increased Tim-3+ monocytes/macrophages are associated with disease severity in patients with IgA nephropathy (30). The gene discussed is LAG3; the disease is IgA glomerulonephritis.