CD117, CXCR5, and PD-1 are mildly expressed within the mDCs subset but remain absent in the pDCs subset as well as across all monocyte subsets (Figure 4A), with PD-1 highly expressed in monocytes in patients with hepatocellular carcinoma, presenting a preference toward M2 polarization and had a deficiency in supporting CD8 T cells (18). Here, PDCD1 is linked to hepatocellular carcinoma.