Although we observed increased viral loads and the absence of ISG expression in Ifnar1-/- mice upon infection with SARS-CoV-2 Omicron BA.1, the overall response to infection in this model was lower compared to our previous study of SARS-CoV-2 D614G infection in hACE2-AAV-transduced WT or Ifnar1-/- mice (21). The gene discussed is IFNAR1; the disease is infection.