To investigate virus replication and interferon-stimulated gene (ISG) induction in hACE2knock-in mice upon infection with SARS-CoV-2 Delta or Omicron (BA.1) variants compared to first-wave SARS-CoV-2 (D614G), mice were infected by inoculation with 2 × 105 plaque-forming units (PFU) of each SARS-CoV-2 variant or mock infected with PBS. This evidence concerns the gene STING1 and infection.