In patients with renal dysfunction, the area under the curve (AUC) for NT-proBNP ranged from 0.66 to 0.89 with a median cut-point of 1980 pg/mL, while in patients with preserved renal function, the AUC ranged from 0.72 to 0.95 with a cut-point of 450 pg/mL [20]. The gene discussed is NPPB; the disease is Abnormal renal physiology.