MGMT and obesity due to melanocortin 4 receptor deficiency: However, using an identical grouping as that in OS analysis (Supplementary Figures 5-10) revealed significant PFS differences between the overweight and obesity group in female patients (p=0.010), patients with methylated MGMT promoter (p=0.030), patients without TERT_C228T promoter mutation (p=0.020), patients without TERT_C250T promoter mutation (p=0.0095) and patients without diabetes (p=0.040).