Studies have shown that antipsychotic compounds haloperidol and clozapine (identified as potential autophagy inhibitors) block aberrant mitophagy and reduce TNF-α and IL-1-β production, prevent demyelination in CPZ models, induce remyelination, and restore MS behavioral deficits (Patergnani et al., 2021). This evidence concerns the gene IL1B and myeloid sarcoma.