MSCs-exosomes have a cardioprotective effect in rats with I/R injury, as shown by a significant reduction in I/R-induced myocardial infarction and a drop in the serum levels of cardiac troponin I (cTnI), lactate dehydrogenase, and creatine kinase-myocardial band. Here, TNNI3 is linked to myocardial infarction.