The results obtained from the study conducted by Kim Dore, reveal that increased PSD-95 can prevent Aβ toxicity for synapses, this also suggests that reduction in levels of PSD-95 may be involved in AD and increases in PSD-95 levels at synapses prevent the synaptic deficits caused by Aβ (Dore et al., 2021[16]). This evidence concerns the gene DLG4 and Alzheimer disease.