Significantly upregulated genes in those with obesity following LPS stimulation included pro-inflammatory (tnfa, il1b and il6) and anti-inflammatory (il-10) cytokines (Figure 3G for RPKM values; Table S5 for all differentially expressed genes), confirming the findings at the protein level. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.