RAC1 and cancer: Ras is an oncogene coding for a GTPase which stimulates cellular proliferation and survival through, amongst others, the PI3K/AKT/mTOR pathway, and is frequently found in mutated form in cancer and was examined by several included studies.64, 65, 66 RhoA and Rac1 are also GTPases and control actin fibre dynamics, cellular adhesion, and cell migration.