We confirmed reduced induction of a subset of genes (IL6, CXCL1, CXCL2, CXCL3, CXCL8, and IL1B) by Omicron BA.1 or BA.2 compared with WT and validated an increase in colony-stimulating factor 3 (CSF3) and tumor necrosis factor (TNF) after infection with all evaluated SARS-CoV-2 strains by quantitative polymerase chain reaction (qPCR) (Fig. 5F). The gene discussed is TNF; the disease is infection.